Mukutanga kwa2025, vaongorori kubva kuYunivhesiti yeWashington neBrigham uye Chipatara chevakadzi (chipatara chekudzidzisa cheHarvard Medical School) vakaburitsa nzira isati yamboitika yekurapa chirwere cheAlzheimer - kufema.xenongasi, iyo isingangodziviriri neuroinflammation uye inoderedza uropi atrophy, asiwo inowedzera kudzivirira neuronal states.

Xenonuye Neuroprotection

Chirwere cheAlzheimer ndicho chinowanzoitika muvanhu, uye chikonzero chacho chinofungidzirwa kuti chine chekuita nekuunganidzwa kweprotein yetau uye beta-amyloid protein muuropi. Kunyange zvazvo kwave kune mishonga inoedza kubvisa aya mapuroteni ane chepfu, haana kubudirira mukuderedza kufambira mberi kwechirwere. Naizvozvo, chisakiso chechirwere chacho kana kuti marapirwo acho hachinzwisiswi zvizere.

Zvidzidzo zvakaratidza kuti inhaledxenoninogona kuyambuka chipingamupinyi cheropa-uropi uye zvakanyanya kunatsiridza chimiro chembeva nemhando dzechirwere cheAlzheimer pasi pemamiriro emurabhoritari.Kuedza kwakakamurwa kuita mapoka maviri, rimwe boka rembeva rakaratidza tau protein accumulation uye rimwe boka raive ne beta-amyloid protein accumulation. Mhedzisiro yekuedza yakaratidza kuti xenon haina kungoita kuti mbeva dzishande, asi zvakare yakasimudzira mhinduro yekudzivirira yemicroglia, iyo yakakosha pakubvisa tau uye beta-amyloid mapuroteni.

Kuwanikwa kutsva uku kutsva, kuratidza kuti neuroprotective mhedzisiro inogona kugadzirwa nekungofema gasi inert. Chidziviso chikuru mumunda wekutsvagisa nekurapa kweAlzheimer ndechekuti zvakanyanya kuoma kugadzira mishonga inogona kuyambuka ropa-brain barriers, uye.xenonanogona kuita izvi.

Zvimwe zvikumbiro zvekurapa zvexenon

1. Anesthesia uye analgesia: Seyakanaka gasi reanesthetic,xenoninoshandiswa zvakanyanya nekuda kwekukurumidza kupinza uye kupora, kunaka kwemoyo kugadzikana uye njodzi yakaderera yemhedzisiro;

2. Neuroprotective effect: Mukuwedzera kune inogona kurapa chirwere cheAlzheimer chataurwa pamusoro apa, xenon yakadzidzwawo kuderedza kukuvara kwehuropi kunokonzerwa neonatal hypoxic-ischemic encephalopathy (HIE);

3. Kuisirwa nhengo uye kudzivirira:Xenoninogona kubatsira kudzivirira nhengo dzevanopa kubva pakukuvadzwa kweischemia-reperfusion, iyo inonyanya kukosha pakuvandudza kubudirira kwekugadzirisa;

4. Radiotherapy sensitization: Zvimwe zvidzidzo zvekutanga zvakaratidza kuti xenon inogona kukwanisa kuwedzera kunzwa kwemamota kune radiotherapy, iyo inopa nzira itsva yekurapa kenza;