Pakutanga kwa2025, vaongorori vanobva kuYunivhesiti yeWashington neBrigham and Women's Hospital (chipatara chekudzidzisa cheHarvard Medical School) vakaburitsa nzira isina kumboitika yekurapa chirwere cheAlzheimer - kufemaxenongasi, iro risingangodziviriri kuzvimba kweuropi chete uye rinoderedza kupera simba kweuropi, asi rinowedzerawo dziviriro yemasero etsinga.

Xenonuye kuchengetedzwa kweuropi

Chirwere cheAlzheimer ndicho chirwere chinowanzo shandiswa mukuderedza tsinga dzeropa muvanhu, uye chikonzero chacho chinofungidzirwa kuti chine chekuita nekuunganidzwa kweproteni yetau neproteni ye beta-amyloid muuropi. Kunyangwe paine mishonga inoedza kubvisa mapuroteni aya ane chepfu, haina kushanda pakunonotsa kufambira mberi kwechirwere. Saka, chikonzero chikuru chechirwere kana kurapwa kwacho hazvinzwisiswi zvizere.

Zvidzidzo zvakaratidza kuti mweya unofemaxenoninogona kuyambuka chipingamupinyi cheropa-uropi uye kuvandudza zvakanyanya mamiriro emakonzo ane mhando dzechirwere cheAlzheimer mumamiriro ezvinhu emurabhoritari.Kuedza uku kwakakamurwa kuita mapoka maviri, boka rimwe remakonzo rakaratidza kuunganidzwa kwemapuroteni etau uye rimwe boka rakaratidza kuunganidzwa kwemapuroteni e beta-amyloid. Mhedzisiro yekuyedza yakaratidza kuti xenon haina kungoita kuti makonzo ashande zvakanyanya, asiwo yakasimudzira mhinduro yekudzivirira ye microglia, iyo inokosha pakubvisa mapuroteni e tau ne beta-amyloid.

Kuwanikwa uku kutsva kutsva, zvichiratidza kuti mhedzisiro yekudzivirira tsinga inogona kuburitswa nekungofema gasi risina simba. Dambudziko guru riripo mukutsvaga nekurapa kweAlzheimer nderekuti zvakaoma zvikuru kugadzira mishonga inogona kuyambuka chipingamupinyi cheropa-uropi, uyexenonvanogona kuita izvi.

Mamwe mashandisirwo ekurapa exenon

1. Anesthesia uye marwadzo: Segasi reanesthetic rakakodzera,xenoninoshandiswa zvakanyanya nekuda kwekukurumidza kwayo kupinza uye kupora, kugara zvakanaka kwemwoyo uye njodzi shoma yemigumisiro yakaipa;

2. Kudzivirira tsinga dzeuropi: Kuwedzera kune mhedzisiro inogona kuitika pakurapa chirwere cheAlzheimer chataurwa pamusoro apa, xenon yakaongororwawo kuderedza kukuvara kweuropi kunokonzerwa ne hypoxic-ischemic encephalopathy (HIE) yevana vacheche;

3. Kuisirwa nhengo uye dziviriro:Xenoninogona kubatsira kudzivirira nhengo dzemuviri dzinopa nhengo kubva mukukuvara kwe ischemia-reperfusion, izvo zvakakosha zvikuru pakuvandudza mwero wekubudirira kwekuisirwa kwemasero;

4. Kunzwa kweRadiotherapy: Dzimwe ongororo dzekutanga dzakaratidza kuti xenon inogona kuwedzera kunzwa kwebundu kuradiotherapy, izvo zvinopa nzira itsva yekurapa kenza;